Exercise-induced Irisin Hormone May Be Muscle Loss Biomarker

Blood levels of irisin, an exercise-induced muscle hormone, are significantly lower in people with Charcot-Marie-Tooth disease (CMT) and associate with muscle strength and quality, a small study shows. The findings suggest that this protein, previously shown to have protective effects against muscle wasting, may be a useful biomarker to…

Through Exercise, I’m Confronting My Specific CMT Weaknesses

With great effort, a woman pulls herself up from a wheelchair and into the back seat of a car. Her body is weak, and she can’t seem to move her legs. She wasn’t always like this, though, unable to walk and barely able to fight. No, she was once a…

Ultra Rare CMT Subtype 2Z Identified in 4 Chinese Families

Scientists in China examined the relationship between genetic mutations in the MORC2 gene and the various disease characteristics in people with the rare Charcot-Marie-Tooth disease subtype 2Z (CMT2Z).  Physicians should consider their study’s findings when working to diagnose unresolved cases showing…

New Gene Mutation Found in Five Family Members with CMTX4, Case Report Shows

A new gene mutation was identified in five family members with X-linked Charcot-Marie-Tooth disease type 4 (CMTX4), a Chinese case report describes. The study, “A Novel AIFM1 Mutation in a Chinese Family with X-linked Charcot-Marie-Tooth disease type 4,” appeared in the journal Neuromuscular Disorders. Mutations in…