News

The fat fraction of the calf muscle is a reliable biomarker for disease progression and treatment response in Charcot-Marie-Tooth disease type 1A (CMT1A), according to a recent study. The study, “Validation of MRC Centre MRI calf muscle fat fraction protocol as an outcome measure in CMT1A,”…

Eating food with high levels of fats was seen to help mitigate damage to the structure of myelin, the protective layer surrounding the nerve cells known to be affected in Charcot-Marie-Tooth disease 1A (CMT1A), in a study using rats. The study, “Targeting myelin lipid metabolism as a potential therapeutic…

Cyclists, walkers, and supporters will gather Aug. 26 in Charlotte, Vermont, to bike, walk, and raise funds to help find a cure for Charcot-Marie-Tooth Disease (CMT) in the fifth annual Cycle 4 CMT. “Funds are what stand in the way between us and a treatment for CMT1A [a…

Use of orthoses such as braces or other special devices can help improve the gait and balance of patients with Charcot-Marie-Tooth disease, but patients don’t always follow recommendations for their use, a review study has found. The study, “The Role of Orthotic Service in Modern Rehabilitation of Patients…

Nine previously unknown mutations in the SBF2 gene were found to cause an extremely rare type of Charcot-Marie-Tooth (CMT) disease, called CMT4B2, in seven families. The data expands the available information on clinical manifestations of the disease, which is extremely…

Regenacy Pharmaceuticals is partnering with the Charcot-Marie-Tooth Association (CMTA) to help develop the investigative therapy ricolinostat and evaluate its potential for Charcot-Marie-Tooth (CMT) in animal models. The collaboration is expected to speed the advancement of the treatment candidate…

A specific rehabilitation protocol improves hand function and is well-tolerated by patients with Charcot-Marie-Tooth disease, according to researchers. The study, “Hand Rehabilitation Treatment for Charcot-Marie-Tooth Disease: An Open Label Pilot Study,” appeared in the Journal of Neurology & Neurophysiology. CMT is characterized by the…

Proprioceptive neuromuscular facilitation (PNF) muscle-stretching exercises can help prevent foot drop in patients with Charcot-Marie-Tooth (CMT) disease type 1A. The finding is reported in the study “Ipsilateral proprioceptive neuromuscular facilitation patterns improve overflow and reduce foot drop in patients with demyelinating polyneuropathy,” led by…

A reanalysis of the genetic profile of a large Costa Rican family revealed that a PNKP gene mutation was to blame for Charcot-Marie-Tooth disease type 2 (CMT2) and not a mutation in the MED25 gene, as had been proposed in an initial evaluation 17 years ago. These findings…

Acceleron’s therapy candidate ACE-083 was seen to improve total and contractile muscle volume in patients with Charcot-Marie-Tooth (CMT) disease in preliminary results from a Phase 2 trial. The study is still recruiting patients. The positive data was presented by Acceleron at this year’s…