Author Archives: Alice Melao

Japanese Team Discovers Five New SH3TC2 Mutations Linked to CMT4

Japanese researchers have identified five new mutations of the SH3TC2 gene that are involved in the development of Charcot-Marie-Tooth type 4 (CMT4). Their findings, in a study titled “Clinical and mutational spectrum of Japanese patients with recessive variants in SH3TC2,” appeared in the Journal of Human…

Mutations in SACS Gene Linked to CMT-Like Symptoms in Two Patients

Mutations on the sequence of the SACS gene can lead to sensorimotor impairment similar to that observed in patients with Charcot-Marie-Tooth disease (CMT), researchers contend in a case report study published at Muscular Disorders. More than 20 genes have been associated with the development of different forms of CMT.

Chemotherapy Drugs May Induce Severe Impairment in CMT Patients, Study Shows

Diagnosis of Charcot-Marie-Tooth disease and other neuropathies is essential to prevent severe, life-threatening complications that may arise from the use of chemotherapy drugs, a study published in the journal Acta Oncologica highlights. Some compounds that are commonly used to fight cancers can induce chemotherapy-induced peripheral neuropathy (CIPN). This is…