Sara Guariglia,  —

As a result of significant reductions in walking and physical therapy, people with Charcot-Marie-Tooth (CMT) disease reported worsening physical skills and pain scores after the COVID-19 lockdowns, a recent survey found. Their responses highlight the need to encourage CMT patients to resume their previous…

The CMT Research Foundation has launched a new research program that will seek to develop a precision medicine approach to treat people with Charcot-Marie-Tooth (CMT) disease, the foundation announced in a press release. The approach focuses on silencing the gene that is causing the disease in each…

Patients with Charcot Marie Tooth Type 1A (CMT1A) disease appear to experience a structural reorganization in their brains, particularly in a region associated with movement and balance called the cerebellum, a recent study found. These alterations, researchers suggest, may be a…

A new formulation of an antioxidant called curcumin may be effective in alleviating the symptoms of Charcot-Marie-Tooth type 1A (CMT1A) disease, a rat study suggests. The formulation was seen to lower oxidative stress and promote nerve cell myelination in a CMT1A rat model, ultimately leading to better sensory…

The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health (NIH), has awarded DTx Pharma a funding grant to advance development of promising new therapeutic candidates for Charcot-Marie-Tooth (CMT) type 1A (CMT1A) disease. The therapeutic candidates are specially designed RNA oligonucleotide…

Three new genetic mutations in the GJB1 gene have been found inn Chinese patients that can cause X-linked Charcot-Marie-Tooth (CMTX1) disease, expanding the diversity of mutations causing the condition, according to a study. While the three mutations were all in coding regions, some previously known mutations were…