Technique Reveals Unique Protein Structure of PMP22

Researchers at the University of Michigan and Vanderbilt University have found that mutant PMP22 proteins pair to form a unique, stabilized complex called a dimer. The discovery, which was made using an advanced protein analysis technique, provides new insight into PMP22’s role in…

Modeling of MFN2 Protein Mutations’ Effects May Predict CMT Type 2A’s Severity

Molecular simulations of the effects of specific mutations in the structure of mitofusin 2 (MFN2) — the key protein altered in Charcot-Marie-Tooth disease type 2A (CMT2A) — may predict the disease’s severity, a recent study shows. The study, “Molecular modelling of mitofusin 2 for a prediction for…