Patient stories are a central theme for the events organized by the Charcot-Marie-Tooth Association (CMTA), Hereditary Neuropathy Foundation (HNF) and others this September as part of the 2018 CMT Awareness Month. A degenerative neuromuscular condition, CMT, affects one in every 2,500 people. It has no known cure. The…
A genetic study in fruit flies has found a new link between Charcot-Marie-Tooth (CMT) disease and amyotrophic lateral sclerosis (ALS). Conducted by researchers from the Kyoto Institute of Technology and collaborators at the Kyoto Prefectural University of Medicine in Japan, the study suggests that long-noncoding RNA molecules are…
Differences in high-resolution nerve ultrasound (HRUS) results could help distinguish patients with Charcot-Marie-Tooth disease type 1A (CMT1A) from those with other disease types characterized by the loss of myelin, a study reports. The study, “Nerve ultrasound findings differentiate Charcot-Marie-Tooth disease (CMT) 1A from other demyelinating CMTs,”…
Children and adolescents with Charcot-Marie-Tooth disease (CMT) fall approximately 33 times more than their peers with normal development, sustaining more injuries when they fall, a study reports. The study, “Falls in paediatric Charcot-Marie-Tooth disease: a 6-month prospective cohort study,” was published in the journal BMJ. CMT patients develop…
The fat fraction of the calf muscle is a reliable biomarker for disease progression and treatment response in Charcot-Marie-Tooth disease type 1A (CMT1A), according to a recent study. The study, “Validation of MRC Centre MRI calf muscle fat fraction protocol as an outcome measure in CMT1A,”…
Eating food with high levels of fats was seen to help mitigate damage to the structure of myelin, the protective layer surrounding the nerve cells known to be affected in Charcot-Marie-Tooth disease 1A (CMT1A), in a study using rats. The study, “Targeting myelin lipid metabolism as a potential therapeutic…
Cyclists, walkers, and supporters will gather Aug. 26 in Charlotte, Vermont, to bike, walk, and raise funds to help find a cure for Charcot-Marie-Tooth Disease (CMT) in the fifth annual Cycle 4 CMT. “Funds are what stand in the way between us and a treatment for CMT1A [a…
Use of orthoses such as braces or other special devices can help improve the gait and balance of patients with Charcot-Marie-Tooth disease, but patients don’t always follow recommendations for their use, a review study has found. The study, “The Role of Orthotic Service in Modern Rehabilitation of Patients…
Nine previously unknown mutations in the SBF2 gene were found to cause an extremely rare type of Charcot-Marie-Tooth (CMT) disease, called CMT4B2, in seven families. The data expands the available information on clinical manifestations of the disease, which is extremely…
Regenacy Pharmaceuticals is partnering with the Charcot-Marie-Tooth Association (CMTA) to help develop the investigative therapy ricolinostat and evaluate its potential for Charcot-Marie-Tooth (CMT) in animal models. The collaboration is expected to speed the advancement of the treatment candidate…
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