News

Molecular Abnormalities Suggest Charcot–Marie–Tooth Starts During Embryonic Development

Researchers have identified molecular abnormalities in cells found during embryonic nerve development that are common to patients with demyelinating Charcot–Marie–Tooth (CMT) disease caused by three different mutations. The findings advance the understanding of how the disease develops, and “further studies focusing on the common molecular signature in demyelinating CMT could reveal a…

Multiple-family Study Links MCM3AP Gene to Development of Charcot-Marie-Tooth Disease

Researchers have identified MCM3AP as a gene involved in the development of a childhood-onset version of the neurological disorder Charcot-Marie-Tooth disease. The study, “MCM3AP in recessive Charcot-Marie-Tooth neuropathy and mild intellectual disability,” was published in the journal Brain. Charcot-Marie-Tooth disease (CMT) is a group of hereditary neuropathies, or diseases affecting…

Patients Who Exercise Regularly Show Greater Strength and Lesser Disability, Study Finds

Routine exercise done at a patient’s own pace improves strength and lessens disability in patients with Charcot-Marie-Tooth (CMT) disease, reports a Canadian study that compared patients adhering to a “self-directed” exercise program with those who do not exercise. The study, “Effects of Self-Selected Exercise on Strength in Charcot–Marie–Tooth Disease…